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Publication type: Journal Article
Document type: Full Paper

Year: 1991

Author(s): Zitterl-Eglseer, K; Jurenitsch, J; Korhammer, S; Haslinger, E; Sosa, S; Della Loggia, R; Kubelka, W; Franz, C

Title: [Sesquiterpenelactones of Achillea setacea with antiphlogistic activity].

Source: Planta Med (57), 5 444-446.

Authors Vetmeduni Vienna:

Franz Chlodwig
Zitterl-Eglseer Karin

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds

From the aerial parts of Achillea setacea W. & K. (Asteraceae) the main sesquiterpenes were isolated. Their structures were determined by means of 2D-NMR and MS as 11, 13-dehydrodeacetylmatricarin (1) (= 14-deoxylactucin), rupicolin A (2), and rupicolin B (3). These are the first compounds with an alpha-methylene-gamma-lactone structure isolated from a species belonging to the Achillea millefolium aggregate. Achillicin, achillin, 8-hydroxyachillin, 8-acetoxyachillin, and matricin could not be detected in A. setacea. For both rupicolin B and 11,13-dehydrodeacetylmatricarin an anti-inflammatory activity was found in the croton oil ear test.

Keywords Pubmed: Anti-Inflammatory Agents, Non-Steroidal - chemistry : Lactones - chemistry : Molecular Structure - chemistry : Phorbols - chemistry : Plants - chemistry : Sesquiterpenes - chemistry

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