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Publication type: Journal Article
Document type: Full Paper

Year: 1997

Author(s): Zitterl-Eglseer, K; Sosa, S; Jurenitsch, J; Schubert-Zsilavecz, M; Della Loggia, R; Tubaro, A; Bertoldi, M; Franz, C

Title: Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.).

Source: J Ethnopharmacol (57), 2 139-144.



Authors Vetmeduni Vienna:

Franz Chlodwig
Zitterl-Eglseer Karin

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds


Abstract:
Separation and isolation of the genuine faradiol esters (1,2) from flower heads of Marigold (Calendula officinalis L., Asteraceae) could be achieved by means of repeated column chromatography (CC) and HPLC for the first time. Structure elucidation of faradiol-3-myristic acid ester 1, faradiol-3-palmitic acid ester 2 and psi-taraxasterol 3 has been also performed, without any previous degradation by means of MS, H-1-NMR, C-13-NMR and 2D-NMR experiments. The anti-oedematous activities of these three compounds were tested by means of inhibition of Croton oil-induced oedema of the mouse ear. Both faradiol esters showed nearly the same dose dependent anti-oedematous activity and no significant synergism appeared with their mixture. The free monol, psi-taraxasterol, had a slightly lower effect. Furthermore, faradiol was more active than its esters and than psi-taraxasterol and showed the same effect as an equimolar dose of indomethacin. (C) 1997 Elsevier Science Ireland Ltd.

Keywords Pubmed: Animals - : Edema - drug therapy : Esters - chemistry : Magnetic Resonance Spectroscopy - chemistry : Male - chemistry : Mass Spectrometry - methods : Mice - methods : Molecular Structure - methods : Plants, Medicinal - chemistry : Triterpenes - chemistry

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