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Selected Publication:

Publication type: Journal Article
Document type: Full Paper

Year: 2009

Author(s): Zitterl, W; Stompe, T; Aigner, M; Zitterl-Eglseer, K; Ritter, K; Zettinig, G; Hornik, K; Asenbaum, S; Pirker, W; Thau, K

Title: Diencephalic serotonin transporter availability predicts both transporter occupancy and treatment response to sertraline in obsessive-compulsive checkers.

Source: Biol Psychiatry. 2009; 66(12):1115-1122



Authors Vetmeduni Vienna:

Zitterl-Eglseer Karin

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds


Abstract:
To our knowledge, no studies have investigated the predictive value of central serotonin transporter (SERT) availability for treatment response to serotonin reuptake inhibitors (SSRIs) in patients with obsessive-compulsive disorder (OCD). This study used brain imaging to examine the relationship between pretreatment SERT availability and transporter occupancy as well as treatment response by sertraline in patients displaying prominent behavioral checking compulsions (OC checkers).

Keywords Pubmed: Adult
Cocaine/analogs & derivatives
Cocaine/diagnostic use
Diencephalon/drug effects
Diencephalon/metabolism*
Diencephalon/radionuclide imaging
Drug Administration Routes
Female
Humans
Male
Middle Aged
Obsessive-Compulsive Disorder*/drug therapy
Obsessive-Compulsive Disorder*/pathology
Obsessive-Compulsive Disorder*/radionuclide imaging
Protein Binding/drug effects
Radiopharmaceuticals/diagnostic use
Serotonin Plasma Membrane Transport Proteins/metabolism*
Serotonin Uptake Inhibitors/pharmacology
Serotonin Uptake Inhibitors/therapeutic use*
Sertraline/pharmacology
Sertraline/therapeutic use*
Statistics as Topic
Tomography, Emission-Computed, Single-Photon/methods
Young Adult


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