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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2010

Authors: Zeugswetter, F; Handl, S; Iben, C; Schwendenwein, I

Title: Efficacy of plasma beta-hydroxybutyrate concentration as a marker for diabetes mellitus in acutely sick cats.

Source: J Feline Med Surg. 2010; 12(4):300-305

Authors Vetmeduni Vienna:

Handl Stefanie
Iben Christine
Schwendenwein Ilse
Zeugswetter Florian

Vetmed Research Units
Clinical Pathology Platform
University Clinic for Small Animals, Clinical Unit of Internal Medicine Small Animals
Institute of Animal Nutrition and Functional Plant Compounds

Urine ketone measurement is routinely performed in cats with diabetes mellitus to identify impending or established ketoacidosis. Studies using the urinary ketone dipstick test have shown that ketonuria is common in cats with newly diagnosed untreated diabetes mellitus. This test has a low sensitivity as it quantifies the less abundant ketone acetoacetate. The objective of the present study was to determine if ketonaemia is an inherent biochemical finding in untreated feline diabetes mellitus by measuring plasma ss-hydroxybutyrate (ss-OHB) in acutely sick cats. In 122 sick cats (37 diabetic and 85 non-diabetic cats) plasma ss-OHB, glucose, fructosamine, total protein and thyroxine were measured as part of the routine work up. Diabetic cats had significantly elevated ss-OHB values and ss-OHB measurement was a sensitive and specific test to identify diabetes mellitus. The area under the receiver operating characteristic (ROC) curve was 0.93. The cut off value with the highest positive likelihood ratio was 0.58 mmol/l. These results suggest that determination of plasma ss-OHB concentration is a useful method to distinguish between diabetic and non-diabetic sick cats.

Keywords Pubmed: 3-Hydroxybutyric Acid/blood*
Blood Glucose/analysis
Case-Control Studies
Cat Diseases/blood*
Cat Diseases/diagnosis
Diabetes Mellitus/blood
Diabetes Mellitus/diagnosis
Diabetes Mellitus/veterinary*
Diabetic Ketoacidosis/blood
Diabetic Ketoacidosis/diagnosis
Diabetic Ketoacidosis/veterinary
Predictive Value of Tests
ROC Curve
Tumor Markers, Biological/blood*

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