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Publication type: Journal Article
Document type: Full Paper

Year: 2012

Author(s): Galler, A; Tran, JL; Krammer-Lukas, S; Höller, U; Thalhammer, JG; Zentek, J; Willmann, M

Title: Blood vitamin levels in dogs with chronic kidney disease.

Source: Vet J. 2012; 192(2):226-231

Authors Vetmeduni Vienna:

Galler Alexandra
Thalhammer Johann
Willmann Michael
Zentek Jürgen

Vetmed Research Units
University Clinic for Small Animals, Clinical Unit of Internal Medicine Small Animals
Institute of Animal Nutrition and Functional Plant Compounds

Chronic kidney disease (CKD) may affect excretion and metabolism of vitamins but data for dogs are limited. In this study, blood vitamin levels were investigated in 19 dogs with chronic renal failure. High performance liquid chromatography was used to quantify retinol, retinyl esters, tocopherol, thiamine, riboflavin, pyridoxal-5"-phosphate, ascorbic acid and 25-hydroxycholecalciferol concentrations, whereas cobalamin, folate, biotin and pantothenic acid were measured by microbiological methods. Levels of retinol, retinyl palmitate, ascorbic acid, and vitamins B1, B2 and B6 were increased compared to healthy dogs. Dogs with CKD showed decreased concentrations of 25-hydroxycholecalciferol and folate. Alpha-tocopherol, biotin, pantothenate and cobalamin levels were not significantly different between controls and dogs with CKD. Whether lower vitamin D and folate concentrations in dogs with CKD justify supplementation has to be evaluated in future studies.

Keywords Pubmed: Animals
Ascorbic Acid/blood
Case-Control Studies
Dog Diseases/blood*
Folic Acid/blood
Kidney Failure, Chronic/blood
Kidney Failure, Chronic/veterinary*
Vitamin A/analogs & derivatives
Vitamin A/blood
Vitamin B 6/blood

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