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Publication type: Journal Article
Document type: Full Paper

Year: 2012

Author(s): Marek, A; Nolte, V; Schachner, A; Berger, E; Schlötterer, C; Hess, M

Title: Two fiber genes of nearly equal lengths are a common and distinctive feature of Fowl adenovirus C members.

Source: Vet Microbiol. 2012; 156(3-4):411-417

Authors Vetmeduni Vienna:

Hess Michael
Marek Ana
Nolte Viola
Schlötterer Christian

Vetmed Research Units
University Clinic for Poultry and Fish Medicine, Clinical Unit of Poultry Medicine
Institute of Population Genetics

The complete genome or the genome region containing the two fiber genes of two reference strains and one field isolate representing both serotypes of Fowl adenovirus C were sequenced. Two fiber genes were revealed in the genomes of all three isolates. Fiber-1 and fiber-2 genes of several Fowl adenovirus C isolates were sequenced as well. Both serotypes 4 and 10 have two fiber genes. The genome region containing the fiber gene was also sequenced for the reference strain of Fowl adenovirus B. Just one fiber gene was revealed in this strain. Predicted amino acid sequences were compared to already published fiber sequences of different adenovirus isolates and one amino acid substitution within fiber-2 was detected in all of the Fowl adenovirus C isolates that were isolated from chickens with hepatitis-hydropericardium syndrome in comparison to apathogenic isolates. Phylogenetic analyses provided insights about the evolution of fiber genes in avian adenoviruses and their genetic relationships.

Keywords Pubmed: Adenoviridae Infections/veterinary*
Adenoviridae Infections/virology
Amino Acid Sequence
Amino Acid Substitution
Base Sequence
Bird Diseases/virology*
DNA, Viral/genetics
Genes, Viral*
High-Throughput Nucleotide Sequencing
Molecular Sequence Data

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