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Publication type: Journal Article
Document type: Full Paper

Year: 2010

Author(s): Meda, NT; Lamien-Meda, A; Kiendrebeogo, M; Lamien, CE; Coulibaly, AY; Millogo-Rasolodimby, J; Nacoulma, OG

Title: In vitro antioxidant, xanthine oxidase and acetylcholinesterase inhibitory activities of Balanites aegyptiaca (L.) Del. (Balanitaceae).

Source: Pak J Biol Sci. 2010; 13(8):362-368



Authors Vetmeduni Vienna:

Lamien-Meda Aline

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds


Abstract:
The present study aimed to test the validity of Balanites aegyptiaca remedies used for the treatment of rheumatisms and mental disorders by examining the antioxidant, xanthine oxidase and acetylcholinesterase inhibitory activities of galls and leaves extracts and fractions. The total phenolics and flavonoids were measured using Folin-Ciocalteu and AlCl3 reagents, respectively. Two methods i.e., FRAP and ABTS were used to estimate the total antioxidant capacity of the plant materials. The FRAP and ABTS antioxidant activities showed that among all extracts and fractions tested, the best antioxidant activities were found with the galls dichloromethane and the leaves ethyl acetate fractions. The antioxidant activities did correlated significantly with the total phenolic and flavonoid contents. The study also showed that B. aegyptiaca galls and leaves fractions exhibited a moderate xanthine oxidase inhibitory activity comparatively to the acetylcholinesterase which was weakly inhibited by the tested extracts and fractions.

Keywords Pubmed: Acetylcholine/metabolism*
Animals
Antioxidants/metabolism*
Balanites*/chemistry
Balanites*/metabolism
Cholinesterase Inhibitors/metabolism*
Flavonoids/isolation & purification
Flavonoids/metabolism
Humans
Phenols/isolation & purification
Phenols/metabolism
Plant Extracts/metabolism*
Plant Extracts/therapeutic use
Reproducibility of Results
Xanthine Oxidase*/antagonists & inhibitors
Xanthine Oxidase*/metabolism


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