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Selected Publication:

Publication type: Journal Article
Document type: Full Paper

Year: 1992

Author(s): Leidinger, E; Loupal, G; Gutleb, R; Miller, I; Chizzola, R

Title: Toxic Effects After Immunization Against The Pyrrolizidin Alkaloid Retrorsin.

Source: Deut Tierarztl Woch. 1992; 99(8): 332-335.


Authors Vetmeduni Vienna:

Chizzola Remigius
Loupal Gerhard
Miller Ingrid

Vetmed Research Units
Institute for Medical Biochemistry
Institute of Animal Nutrition and Functional Plant Compounds
Institute of Pathology


Abstract:
Six rabbits were immunized against the pyrrolizidine alkaloid retrorsin, conjugated to bovine serum albumin. Seven i. v. inoculations were distributed over a period of half a year. The total antigen dose differed between animals. Towards the end of the experiment all animals (except 2 receiving the lowest antigen dose) suffered from apathy, anorexia and loss of body weight. Pathologically these symptoms correlated well with liver cirrhosis, gradually dependent on the total antigen dose. Blood-chemical parameters were disparate and contradictory.


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