Type of publication:
Type of document:
Marasco, V; Boner, W; Griffiths, K; Heidinger, B; Monaghan, P
Repeated exposure to challenging environmental conditions influences telomere dynamics across adult life as predicted by changes in mortality risk.
FASEB J. 2021; 35(8):e21743
Authors Vetmeduni Vienna:
Vetmed Research Units
Konrad Lorenz Institute of Ethology, Unit of Ornithology
An avian model for understanding adaptations and modulatory drivers of avian migration
How does environmental stress modulate migratory strategies?
- The effects of stress exposure are likely to vary depending on life-stage and stressor. While it has been postulated that mild stress exposure may have beneficial effects, the duration of such effects and the underlying mechanisms are unclear. While the long-term effects of early-life stress are relatively well studied, we know much less about the effects of exposure in adulthood since the early- and adult-life environments are often similar. We previously reported that repeated experimental exposure to a relatively mild stressor in female zebra finches, first experienced in young adulthood, initially had no effect on mortality risk, reduced mortality in middle age, but the apparently beneficial effects disappeared in old age. We show here that this is underpinned by differences between the control and stress-exposed group in the pattern of telomere change, with stress-exposed birds showing reduced telomere loss in middle adulthood. We thereby provide novel experimental evidence that telomere dynamics play a key role linking stress resilience and aging.© 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.