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Type of publication: Journal Article
Type of document: Full Paper

Year: 2021

Authors: Kósa, CA; Nagy, K; Szenci, O; Baska-Vincze, B; Andrásofszky, E; Szép, R; Keresztesi, Á; Mircean, M; Taulescu, M; Kutasi, O

Title: The role of selenium and vitamin E in a Transylvanian enzootic equine recurrent rhabdomyolysis syndrome.

Source: Acta Vet Hung. 2021; 69(3):256-265

Authors Vetmeduni Vienna:

Korbacska-Kutasi Orsolya

Vetmed Research Units
University Equine Clinic, Clinical Unit of Equine Internal Medicine

A severe form of recurrent exertional rhabdomyolysis occurs enzootically in a well-defined region of Transylvania, Harghita county. At the highest lying two settlements (more than 800 m above sea level), the prevalence of equine rhabdomyolysis is between 17 and 23%, while in the neighbouring villages in the valley it is less than 2%. The objective of our study was to clarify the role of selenium and vitamin E in the high prevalence of rhabdomyolysis in that region. Soil and hay samples were collected from each area to evaluate mineral content. Ten horses from the non-affected and 20 horses from the affected area were tested for serum selenium, vitamin E, glutathione peroxidase (GSH-Px), muscle enzymes, lactate and electrolytes. Hay samples collected from the affected area had lower selenium content. Horses in the affected regions had significantly lower serum selenium (P = 0.006) and GSH-Px levels than animals living in the non-affected regions. A good correlation between erythrocyte GSH-Px and serum selenium concentration could be demonstrated (r = 0.777, P < 0.001). Serum vitamin E levels were low independently of the origin of the horse. Based on our results, selenium deficiency possibly has a role in the Transylvanian enzootic equine recurrent rhabdomyolysis syndrome.

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