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Publication type: Journal Article
Document type: Full Paper

Year: 2011

Author(s): Yunus, AW; Ghareeb, K; Abd-El-Fattah, AA; Twaruzek, M; Böhm, J

Title: Gross intestinal adaptations in relation to broiler performance during chronic aflatoxin exposure.

Source: Poult Sci. 2011; 90(8):1683-1689



Authors Vetmeduni Vienna:

Abd-Elfattah Ahmed
Böhm Josef
Ghareeb Khaled

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds


Abstract:
The present trial was conducted to study some morphological, digestive, and electrophysiological variables of the small intestine during chronic exposure of broilers to aflatoxin B(1) (AFB(1)). Ross 308 male chicks (7 d old) were randomly allotted to control (no AFB(1)), low AFB(1) (0.07 mg of AFB(1)/kg), or high AFB(1) (0.75 mg of AFB(1)/kg) diet. The high AFB(1) diet resulted in reduced (P ≤ 0.002) bird performance during the first 4 wk of exposure, whereas the low AFB(1) diet temporarily reduced (P = 0.034) the bird performance during wk 3 of exposure. During wk 4 of exposure, a linear (P ≤ 0.013) decrease in the unit weight of both the duodenum and jejunum was observed with increasing levels of AFB(1). This reduction in unit weight appeared to progress from the proximal (duodenum) to the distal (jejunum) small intestine with increase in the length of exposure and was not accompanied by modulation of electrophysiological variables in jejunal epithelium. Response from amiloride, a specific blocker of epithelial sodium channel, was also similar among jejunal epithelia of birds under different treatments. Interestingly, a compensatory linear (P ≤ 0.002) increase in the length of the duodenum and jejunum under high AFB(1) diets was noted to occur during wk 4 of exposure. Thus, retention of DM and nitrogen was not negatively affected by the AFB(1) diets. These data indicate that the intestine in broilers may adapt to an ongoing dietary challenge to AFB(1).

Keywords Pubmed: Adaptation, Physiological
Aflatoxin B1/toxicity*
Animal Feed/analysis
Animals
Chickens*
Diet/veterinary
Digestion/drug effects
Drug Administration Schedule
Food Contamination*
Intestines/anatomy & histology
Intestines/drug effects*
Intestines/physiology
Male
Poultry Diseases/chemically induced*


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