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Publication type: Journal Article
Document type: Full Paper

Year: 2014

Author(s): Haake, M; Palzer, A; Rist, B; Weissenbacher-Lang, C; Fachinger, V; Eggen, A; Ritzmann, M; Eddicks, M

Title: Influence of age on the effectiveness of PCV2 vaccination in piglets with high levels of maternally derived antibodies.

Source: Vet Microbiol. 2014; 168(2-4):272-280



Authors Vetmeduni Vienna:

Ritzmann Mathias
Weissenbacher-Lang Christiane

Vetmed Research Units
Institute of Pathology
University Clinic for Swine


Abstract:
Two field studies were conducted to investigate the influence of age on the efficacy of vaccination against Porcine Circovirus Diseases (PCVD) in animals with high levels of maternally derived antibodies (MDA). A total of 416 piglets (Study 1) and 600 piglets (Study 2) were randomly allocated to one of three groups. Two groups in each study received a single dose of a PCV2 subunit vaccine, one group at 1 week old and the other at 3 weeks of age. The third group was left untreated. Animals vaccinated at 3 weeks of age showed a significantly higher average daily weight gain and significantly reduced viraemia following PCV2 infection than the respective control groups. This difference was not observed in pigs vaccinated at 1 week of age. Furthermore, only animals vaccinated at 3 weeks of age showed an increased serological response and a higher frequency of IgM-positive animals compared with controls. The data indicated that PCV2 vaccination in the presence of high MDA levels is efficacious when used in 3-week old but not in 1-week old pigs. As the range of MDA titres of pigs vaccinated at both 1 and 3 weeks of age were comparable, the data suggest that PCV2 vaccine efficacy was independent of the level of MDA. It appears that other age-related factors affecting the active and passive transfer of immunity may perhaps have interfered with the efficacy of the vaccine in 1-week old piglets. These findings have implications for future PCV2 vaccine testing and administration strategies.

Keywords Pubmed: Age Factors
Animals
Animals, Newborn
Antibodies, Viral/blood
Antibodies, Viral/immunology
Circoviridae Infections/prevention & control
Circoviridae Infections/veterinary*
Circovirus/immunology*
Female
Immunity, Maternally-Acquired/immunology*
Male
Random Allocation
Sus scrofa
Swine
Swine Diseases/immunology
Swine Diseases/prevention & control*
Swine Diseases/virology*
Vaccines, Subunit/administration & dosage
Vaccines, Subunit/immunology
Viral Vaccines/administration & dosage*
Viral Vaccines/immunology
Viremia/prevention & control
Viremia/veterinary


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