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Publication type: Diploma Thesis

Year: 2011

Author(s): Burkert, Eva

Title: Vergleich pflanzlicher Nahrungsergänzungsmittel bzw. Futtermittel mit Human- bzw. Veterinär-Phytopharmaka von den Pflanzen Ginkgo, Preiselbeere und Weinrebe mit besonderem Augenmerk auf Ginkgolsäuren.

Other title: Comparison of nutraceuticals, feed stuff, human and veterinary phytopharmaceuticals containing the plants ginkgo, cranberries/lingonberries and grape wine with special regards to ginkgolic acids.

Source: Diplomarbeit, Vet. Med. Univ. Wien, pp. 168.


Hahn-Ramssl Isabella
Zitterl-Eglseer Karin

Iben Christine

Vetmed Research Units:
Institute of Animal Nutrition and Functional Plant Compounds

Graduation date: 30.06.11

The aim of this work was to compare nutritional supplements for humans and animals with pharmaceutical products. The plants in question were ginkgo, grape - vine and lingonberry / cranberry. The first thing to do was to find out the widespread of products in Germanspeaking- countries (Austria, Germany and Switzerland). Just one of the products we found was a real pharmaceutical product (Tebofortan®); the rest of them were nutritional supplements. Selected products of all of the three plants were bought. We compared the ingredients and prices of these products, package inserts and the origin (pharmacies, chemist shops, and internet). The fact, that the products bought in pharmacies were mostly the cheapest, was very interesting. We analyzed the Ginkgo-products concerning to ginkgolic acids. Ginkgolic - acids are potential harmful substances in ginkgo biloba leaves. The allowed maximum daily intake for humans is 5 ppm. In ginkgo - products with higher amounts of ginkgolic acids these acids have to be eliminated, and because of that, special ginkgo-extracts are produced. In ginkgo-products containing high amounts of ginkgolic-acids very probably no extracts are used, but whole ginkgo-leaves. To detect the ginkgolic-acids, thin-layer-chromatography (qualitative analysis) and HPLC (high performance liquid chromatography) (quantitative analysis) were used. In some of these products, ginkgolic-acids were notedly increased. For Veterinary products, there are no maximum levels of ginkgolic-acids prescribed. Some products are potentially dangerous to health for humans, because of the notedly increased ginkgolic-acid-concentrations.

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