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Publication type: Diploma Thesis

Year: 2011

Author(s): Graage, Robert

Title: PRRSV Challenge nach Impfung mit heterologem Genotyp.

Other title: PRRSV challenge after vaccination with a heterologous genotype

Source: Diplomarbeit, Vet. Med. Univ. Wien, pp. 41.


Ladinig Andrea
Ritzmann Mathias

Saalmüller Armin

Vetmed Research Units:
University Clinic for Swine

Graduation date: 05.05.11

“Porcine reproductive and respiratory syndrome virus” (PRRSV) is one of the most common agents causing the “Porcine Respiratory Disease Complex” and leads to serve economical losses (CHOI et al. 2003). So it is important to minimise the economic effect caused by PRRSV with several management strategies. The vaccination against PRRSV is an important aid with regard to these management strategies (DEE et al. 2003). The genetic variability of the isolated PRRSV field strains is a critical factor which directly influences the efficiency of the vaccination protection (MARTELLI et al. 2009). The efficiency of the vaccination is depending on the used vaccine and on the particular field isolate. According to OKUDA et al. (2008) the vaccine should be as homologue as possible to the circulating field strain to offer an adequate protection but there are other authors who do not see a correlation between homology of field and vaccine virus with efficiency of a vaccine (OPRIESSNIG et al. 2005). On account of the economic meaning of a PRRSV infection, many studies were conducted to evaluate the protection of a vaccination against a heterologous field infection (KOVACS et al. 2003; OKUDA et al. 2008; MARTELLI et al. 2009; ELLINGSON et al. 2010). The objective of this study was to test the efficacy of protection of a modified US-type live vaccine after challenge with a heterologous EU-type field isolate of PRRSV by evaluating clinical signs and pathomorphological lesions

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