Infection with influenza A virus causes an acute, highly contagious respiratory disease in pigs. This disease is widespread in pig producing countries and characterized by high morbidity and low lethality (BROWN, 2000; MAYR u. KAADEN, 2007). Typical clinical symptoms are enhanced abdominal breathing, dyspnoea, coughing, raised body temperature (40,5°C to 42,0°C), apathy and anorexia (LOEFFEN et al., 1999; HEINRITZI, 2006). Characteristic pathological changes are often limited to apical and cranial lung lobes and to the ventral part of the lungs. Usually there is an interstitial pneumonia. The bronchial and mediastinal lymph nodes are generally enlarged (VALHEIM et al., 2011; VAN REETH et al., 2012). Histopathological findings are an interstitial pneumonia, with necrosis and desquamation of the bronchiolar epithelium. Furthermore necrosis of the type-1 pneumocytes, subepithelial and periepithelial infiltrates of mononuclear inflammatory cells occur. The bronchiolar lumina are plugged with necrotic epithelial and inflammatory cells, mainly neutrophilic granulocytes (KHATRI et al., 2010; GROSSE BEILAGE et al., 2013). In this study we examined if an infection of rearing piglets with a H1N2 influenza subtype, will lead to classical clinical symptoms and typical gross pathological and histopathological lesions.