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Type of publication: Baccalaureate Thesis
Type of document:

Year: 2011

Authors: Scholl, Theresa

Title: Characterisation and treatment of a NPM-ALK positive ALCL mouse model.

Other title: Charakterisierung und Behandlung eines NPM-ALK positiven ALCL Maus Modells

Source: Bakkalaureatsarbeit, Vet. Med. Univ. Wien, pp. 28.


Walter Ingrid

Rülicke Thomas

Vetmed Research Units:
Institute of Morphology

Graduation date: 26.09.11

The first description of the anaplastic large cell lymphoma (ALCL) took place in 1985 (STEIN et al., 1985). It is a high malignant T-cell neoplasm with predominant nodular- or extranodular types (DIEBOLD, 2001). Some of these lymphomas have a chromosomal translocation, which results in a fusion of nucleophosmin (NPM) and the anaplastic lymphoma kinase (ALK). The resulting protein (p80) is responsible for the pathogenesis and relevant for diagnose and therapy. The so-called NPM-ALK positive ALCL is mainly found in young adolescence (FALINI et al., 2009). The treatment of patients with ALCL is based on the same chemotherapeutics (CHOP-based regimens) as used for diffuse large B-cell lymphoma patients. About 80% of the children and 60% of the adults suffering from ALK positive lymphomas are cured by this therapy (FALINI et al., 1999). However, there is a novel therapy approach for healing this kind of lymphoma. Scientists from the medical university of Vienna found that there exists an overexpression of the PDGFR-ß in murine and also in human NPM-ALK positive ALCL.

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