Feline immunodeficiency virus (FIV) is a lentivirus causing an AIDS-like disease in cats.
Animals infected by FIV show similar characteristics to human infections with human
immunodeficiency virus (HIV), e.g. reductions in the ratios of CD4+ to CD8+ T-cells. The
differences in pathogenicity of FIV strains can mirror the range of symptomes associated
with HIV infection. The aim of this study is to investigate effectors involved in transcription of
cellular genes in view of discover similar affected pathways to HIV-infection. Therefore we
used two different FIV virus strains, FIV Petaluma and FIV Glasgow 8, which are known to
display different pathogenicities. FIV Petaluma (PET) is considered to be a strain with low
virulence which causes only low plasma viral loads in infected cats and has no effect on the
numbers of CD4+ and CD8+ T-cells whereas highly pathogenic FIV Glasgow 8 strain (GL8)
leads to high viral loads and significant reductions of CD4+/CD8+ T-cell ratios. The infectiontarget
used was Crandells feline kidney cells (CrFK).