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Publication type: Journal Article
Document type: Case Report

Year: 2006

Author(s): Sipos, W; Gerner, W; Schilcher, F; Leeb, C; Groiss, S; Miller, I; Saalmüller, A; Schmoll, F; Schwendenwein, I

Title: Immunophenotypic characterization of peripheral blast cells in a leukemic miniature pig.

Source: Vet Pathol. 2006; 43(3):362-367



Authors Vetmeduni Vienna:

Gerner Wilhelm
Leeb Christine
Miller Ingrid
Saalmüller Armin
Schilcher Franz
Schmoll Friedrich
Schwendenwein Ilse
Sipos Wolfgang

Vetmed Research Units
Clinical Pathology Platform
Institute for Medical Biochemistry
Institute of Immunology
Institute of Pathology
University Clinic for Swine
VetFarm


Abstract:
The health status of a 4-year-old female, dd-haplotype miniature pig deteriorated rapidly, so the animal finally had to be euthanized because of poor clinical condition. Necropsy revealed a massive leukocytic infiltration in the parenchymatous organs of the abdominal cavity. On hematologic cell counting, severe leukocytosis (69.3 x 10(9) cells/liter) and high-grade basophilia (6.9 x 10(9) cells/liter) were evident. Cytologic examination, as well as analysis of expression of leukocyte differentiation antigens by means of flow cytometry, classified blasts, which accounted for about 22% of leukocytes, as biphenotypic cells co-expressing the myeloid marker SWC3 (CD172a) and the lymphoid markers CD5 and CD25. Hematologic features resembled those seen in humans with chronic myeloid leukemia at blast phase.

Keywords Pubmed: Animals
Female
Immunophenotyping
Leukemia/immunology
Leukemia/metabolism
Leukemia/pathology
Leukemia/veterinary*
Leukocytes/immunology
Leukocytes/metabolism*
Liver/pathology
Ovary/pathology
Swine
Swine Diseases/blood*
Swine Diseases/immunology*
Swine Diseases/metabolism
Tumor Markers, Biological/metabolism


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