University of Veterinary Medicine Vienna - Research portal

Diagrammed Link to Homepage University of Veterinary Medicine, Vienna

Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2006

Authors: Shibly, S; Schmidt, P; Robert, N; Walzer, C; Url, A

Title: Immunohistochemical screening for viral agents in cheetahs (Acinonyx jubatus) with myelopathy.

Source: Vet Rec. 2006; 159(17):557-561


Authors Vetmeduni Vienna:

Schmidt Peter
Shibly Sarina
Url Angelika
Walzer Christian

Vetmed Research Units
Institute of Pathology
Research Institute of Wildlife Ecology


Project(s): Mutations in the mitochondrial DNA of cheetahs as possible causes for disease predisposition and neurological degenerations


Abstract:
Numerous cases of acute-onset progressive ataxia, hindlimb paresis and paralysis of unknown aetiology occurred during 1993 to 2003 in cheetahs (Acinonyx jubatus) within the European Endangered Species Programme (eep). This study describes the immunohistochemical investigation of a possible viral aetiology of the "cheetah myelopathy". Antibodies to feline herpesvirus type 1, canine distemper virus, canine parvovirus and Borna disease virus were applied to formalin-fixed and paraffin-embedded brain and spinal cord sections from 25 affected cheetahs aged between three-and-a-half months and 13 years. Using the avidin-biotin complex technique, none of the antibodies gave positive immunosignals in either the brain or the spinal cord tissue.

Keywords Pubmed: Acinonyx/virology*
Animals
Antibodies, Viral/immunology
Brain/pathology
Central Nervous System Viral Diseases/diagnosis
Central Nervous System Viral Diseases/veterinary*
Central Nervous System Viral Diseases/virology
Female
Immunohistochemistry/methods
Immunohistochemistry/veterinary*
Male
Spinal Cord/pathology
Spinal Cord Diseases/diagnosis
Spinal Cord Diseases/veterinary*
Spinal Cord Diseases/virology


© University of Veterinary Medicine ViennaHelp and Downloads