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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2006

Authors: Shibly, S; Schmidt, P; Robert, N; Walzer, C; Url, A

Title: Immunohistochemical screening for viral agents in cheetahs (Acinonyx jubatus) with myelopathy.

Source: Vet Rec. 2006; 159(17):557-561

Authors Vetmeduni Vienna:

Schmidt Peter
Shibly Sarina
Url Angelika
Walzer Christian

Vetmed Research Units
Institute of Pathology
Research Institute of Wildlife Ecology

Project(s): Mutations in the mitochondrial DNA of cheetahs as possible causes for disease predisposition and neurological degenerations

Numerous cases of acute-onset progressive ataxia, hindlimb paresis and paralysis of unknown aetiology occurred during 1993 to 2003 in cheetahs (Acinonyx jubatus) within the European Endangered Species Programme (eep). This study describes the immunohistochemical investigation of a possible viral aetiology of the "cheetah myelopathy". Antibodies to feline herpesvirus type 1, canine distemper virus, canine parvovirus and Borna disease virus were applied to formalin-fixed and paraffin-embedded brain and spinal cord sections from 25 affected cheetahs aged between three-and-a-half months and 13 years. Using the avidin-biotin complex technique, none of the antibodies gave positive immunosignals in either the brain or the spinal cord tissue.

Keywords Pubmed: Acinonyx/virology*
Antibodies, Viral/immunology
Central Nervous System Viral Diseases/diagnosis
Central Nervous System Viral Diseases/veterinary*
Central Nervous System Viral Diseases/virology
Spinal Cord/pathology
Spinal Cord Diseases/diagnosis
Spinal Cord Diseases/veterinary*
Spinal Cord Diseases/virology

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