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Type of publication: Journal Article
Type of document: Full Paper

Year: 2001

Authors: Mayr, B; Gr√ľneis, C; Brem, G; Reifinger, M; Schaffner, G; Hochsteiner, W

Title: Lack of sequence variation in sporadic bovine leucosis in regions of tumour suppressor genes p53 and p16.

Source: J Vet Med A Physiol Pathol Clin Med. 2001; 48(6):365-371

Authors Vetmeduni Vienna:

Brem Gottfried
Hochsteiner Werner
Mayr Burkhard
Reifinger Martin

Vetmed Research Units
University Clinic for Ruminants, Clinical Unit of Ruminant Medicine
Institute of Animal Breeding and Genetics
Institute of Pathology

Regions of the promoter and exons 5-8 of the tumour suppressor gene p53 were analysed in 25 cases of sporadic bovine leucosis. The study included 17 cases of juvenile leucosis, five cases of adult leucosis and three cases of skin leucosis. Exon 2 of tumour suppressor gene p16 was also investigated in the same samples. No sequence variations were present in the analysed areas of the genes. In p53, this fact represents a clear difference in comparison with enzootic bovine leucosis. In p16, no comparative data are available.

Keywords Pubmed: Amino Acid Sequence
Base Sequence
Deltaretrovirus Infections/genetics
Deltaretrovirus Infections/veterinary
Enzootic Bovine Leukosis/genetics*
Genes, p16/genetics*
Genes, p53/genetics*
Molecular Sequence Data
Promoter Regions, Genetic/genetics

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