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Publication type: Journal Article
Document type: Full Paper

Year: 2000

Author(s): Salmons, B; Miethke, T; Wintersperger, S; Müller, M; Brem, G; Günzburg, WH

Title: Superantigen expression is driven by both mouse mammary tumor virus long terminal repeat-associated promoters in transgenic mice.

Source: J Virol. 2000; 74(6):2900-2902



Authors Vetmeduni Vienna:

Brem Gottfried
Günzburg Walter
Müller Mathias

Vetmed Research Units
Institute of Animal Breeding and Genetics
Institute of Virology


Abstract:
In addition to the usual retroviral promoter, the mouse mammary tumor virus (MMTV) long terminal repeat carries a second promoter located in the U3 region. Here we show that both of these promoters are independently able to give rise to superantigen activity in transgenic mice. The ability of multiple MMTV promoters to drive superantigen expression underscores its importance in the virus life cycle.

Keywords Pubmed: Animals
Antigens, Viral/genetics*
Gene Expression Regulation, Viral*
Mammary Tumor Virus, Mouse/genetics*
Mice
Mice, Inbred C57BL
Mice, Transgenic
Promoter Regions, Genetic*
Superantigens/biosynthesis
Superantigens/genetics*
Terminal Repeat Sequences*


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