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Publication type: Journal Article
Document type: Full Paper

Year: 2002

Author(s): Haider, T; Sommer, R; Knasm├╝ller, S; Eckl, P; Pribil, W; Cabaj, A; Kundi, M

Title: Genotoxic response of Austrian groundwater samples treated under standardized UV (254 nm)--disinfection conditions in a combination of three different bioassays.

Source: Water Res. 2002; 36(1):25-32

Authors Vetmeduni Vienna:

Cabaj Alexander

Vetmed Research Units
Institute of Physiology, Pathohysiology and Biophysics, Unit of Physiology and Biophysics

Project(s): UV-Disinfection of water

Ground water samples from different geographic areas in Austria, with different amounts of natural and anthropogenic organic compounds were treated with a standardized low pressure UV (254 nm)-irradiation laboratory flow-through system (UV fluence: 800 J/m2). The genotoxic activities of the water samples before and after the UV disinfection were investigated using a combination of three different bioassays which complement each other with regard to their sensitivity detecting different genotoxins. The test battery comprises the Salmonella/microsome assay (Ames test with TA98. TA 100 and TA 102, with and without S9 mix) and two micronucleus tests with the plant Tradescantia (clone #4430) and with primary rat hepatocytes. Overall, the tested Austrian groundwater samples used for human consumption caused only weak genotoxic activities compared to drinking water samples reported from other countries under similar experimental conditions. With the exception of one weak positive result in the Ames test (only in strain TA98 without S9 mix) with an induction factor of 1.9) all samples after UV disinfection were devoid of additional mutagenic and clastogenic activities compared to the samples before UV disinfection.

Keywords Pubmed: Animals
DNA Damage*
Hepatocytes/drug effects
Micronucleus Tests
Mutagenicity Tests
Salmonella typhimurium/drug effects
Salmonella typhimurium/genetics
Soil Pollutants/adverse effects*
Ultraviolet Rays
Water Pollutants/adverse effects*
Water Purification*
Water Supply*

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