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Publication type: Journal Article
Document type: Full Paper

Year: 2003

Author(s): Klymiuk, N; Müller, M; Brem, G; Aigner, B

Title: Recombination analysis of human-tropic porcine endogenous retroviruses.

Source: J Gen Virol. 2003; 84(Pt 10):2729-2734



Authors Vetmeduni Vienna:

Aigner Bernhard
Brem Gottfried
Müller Mathias

Vetmed Research Units
Institute of Animal Breeding and Genetics


Abstract:
Prevention of cross-species infection of porcine endogenous retroviruses (PERV) is crucial for xenotransplantation. The potential risk of infection is caused by replication-competent PERV as well as by hybrid viruses derived from recombination events of distinct PERV genomes. Recently, human-tropic, replication-competent PERV genomes obtaining hybrid sequences have been observed. Here, complete polymorphism pattern analysis was performed on the full-length PERV gamma1 clones and on the complete envelope (env) gene sequences published to date. Several recombined full-length clones and a high number of different recombination patterns in the env gene were identified. In addition, recombinations with retroviral genomes not yet known were found. Thus, the potential risk of infection also exists for recombination products, including defective PERV loci.

Keywords Pubmed: Animals
Base Sequence
Cell Line
Endogenous Retroviruses/genetics*
Endogenous Retroviruses/physiology
Genes, env/genetics
Genome, Viral
Humans
Molecular Sequence Data
Recombination, Genetic*
Sequence Analysis, DNA
Swine/virology*
Virus Replication


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