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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 1999

Authors: Reichart, U; Renner-Muller, I; Kappler, R; Scherthan, H; Wolf, E; Muller, M; Brem, G; Aigner, B

Title: Novel leptin receptor gene deficient animal model caused by an insertional mutation in transgenic mice.

Source: Arch Tierzucht 1999; 42: 153-155.

Authors Vetmeduni Vienna:

Aigner Bernhard
Brem Gottfried
Müller Mathias

Vetmed Research Units
Institute of Animal Breeding and Genetics

Examination of random insertional mutations in transgenic animals harbouring an abnormal phenotype contributes to the discovery of new genes and/or the understanding of the function of already known genes. We revealed a partial deletion of the leptin receptor (Ob-R) gene in a transgenic mouse line harbouring an insertional mutation. In the homozygous mutant mice of the outbred strain used, a strong variation of the obesity and diabetes phenotype was observed. The leptin receptor defective mice of this line might serve as a model for the investigation of genes modulating the development and mode of expression of diabetes.

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