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Selected Publication:

Publication type: Journal Article
Document type: Full Paper

Year: 1999

Author(s): Reichart, U; Renner-Muller, I; Kappler, R; Scherthan, H; Wolf, E; Muller, M; Brem, G; Aigner, B

Title: Novel leptin receptor gene deficient animal model caused by an insertional mutation in transgenic mice.

Source: Arch Tierzucht 1999; 42: 153-155.

Authors Vetmeduni Vienna:

Aigner Bernhard
Brem Gottfried
Müller Mathias

Vetmed Research Units
Institute of Animal Breeding and Genetics


Abstract:
Examination of random insertional mutations in transgenic animals harbouring an abnormal phenotype contributes to the discovery of new genes and/or the understanding of the function of already known genes. We revealed a partial deletion of the leptin receptor (Ob-R) gene in a transgenic mouse line harbouring an insertional mutation. In the homozygous mutant mice of the outbred strain used, a strong variation of the obesity and diabetes phenotype was observed. The leptin receptor defective mice of this line might serve as a model for the investigation of genes modulating the development and mode of expression of diabetes.


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