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Publication type: Journal Article
Document type: Full Paper

Year: 1999

Author(s): Mayr, B; Reifinger, M; Brem, G; Feil, C; Schleger, W

Title: Cytogenetic, ras, and p53: Studies in cases of canine neoplasms (hemangiopericytoma, mastocytoma, histiocytoma, chloroma).

Source: J Hered 1999; 90(1): 124-128.

Authors Vetmeduni Vienna:

Brem Gottfried
Reifinger Martin

Vetmed Research Units
Institute of Animal Breeding and Genetics
Institute of Pathology

Four case reports of mesenchymal neoplasms showing chromosomal abnormalities are presented, In a case of hemangiopericytoma trisomy 2 and centric fusion 19;21 were present. In a mastocytoma a deleted chromosome 35 was seen, A homogeneously staining region (HSR) on chromosome 1 was detected in a histiocytoma, Trisomy 5 and monosomy 31 were observed in a case of granulocytic sarcoma (chloroma). The lack of mutations in exons 1 and 2 of oncogenes N-ras, Kras, and H-ras and exons 5, 6, 7, and 8 of tumor suppressor gene p53 in these four patients and in a larger series of investigated dogs (25 hemangiopericytomas, 12 mastocytomas, and 8 histiocytomas) is highlighted.

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