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Publication type: Journal Article
Document type: Full Paper

Year: 2000

Author(s): Mayr, B; Blauensteiner, J; Edlinger, A; Reifinger, M; Alton, K; Schaffner, G; Brem, G

Title: Presence of p53 mutations in feline neoplasms.

Source: Res Vet Sci. 2000; 68(1):63-70

Authors Vetmeduni Vienna:

Brem Gottfried
Reifinger Martin

Vetmed Research Units
Institute of Animal Breeding and Genetics
Institute of Pathology

A region from exon 4 to 8 of the tumour suppressor gene p53 was analysed in 60 feline tumours (30 fibrosarcomas, seven malignant histiocytomas, three lymphosarcomas, five basal cell tumours, five squamous cell carcinomas, two adenocarcinomas of tubular skin glands, one undifferentiated carcinoma of the skin, seven mammary carcinomas). Missense mutations were detected in two fibrosarcomas, one malignant fibrous histiocytoma, the undifferentiated carcinoma of the skin and one mammary carcinoma. One nonsense mutation was detected in one fibrosarcoma and one deletion/frameshift-mutation was observed in one squamous cell carcinoma.

Keywords Pubmed: Animals
Cat Diseases/genetics*
Cat Diseases/pathology
DNA, Neoplasm/genetics
Frameshift Mutation
Genes, p53*
Mutation, Missense
Polymerase Chain Reaction
Sequence Deletion

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