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Publication type: Journal Article
Document type: Full Paper

Year: 2000

Author(s): Reichart, U; Renner-Müller, I; Höflich, A; Müller, OJ; Franz, WM; Wolf, E; Müller, M; Brem, G; Aigner, B

Title: Contrasting obesity phenotypes uncovered by partial leptin receptor gene deletion in transgenic mice.

Source: Biochem Biophys Res Commun. 2000; 269(2):502-507



Authors Vetmeduni Vienna:

Aigner Bernhard
Brem Gottfried
Müller Mathias
Reichart Ursula

Vetmed Research Units
Institute of Animal Breeding and Genetics


Abstract:
Non-insulin-dependent diabetes mellitus (type 2 diabetes) is known to be a polygenic and polyfactorial disorder. Here we describe the long-term examination of a transgenic mouse line showing the disruption of the leptin receptor (Lepr, Ob-R) gene caused by transgene insertion. The absence of the expression of the long isoform Ob-Rb uncovered a strong variation of the obesity and diabetes phenotype in the homozygous mutant mice of the outbred strain used. One part of the homozygous mice developed severe persistent early-onset obesity, whereas the other part developed cachexia after having shown initial obesity in the examination period up to 26 weeks p.p. The leptin-receptor-defective mice of this line might serve as a model for the investigation of genes modulating the development and mode of expression of diabetes.

Keywords Pubmed: Animals
Body Weight/genetics
Carrier Proteins/genetics*
Carrier Proteins/metabolism
Diabetes Mellitus, Type 2/genetics
Female
Gene Deletion*
Homozygote
Leptin/blood
Male
Mice
Mice, Mutant Strains
Mice, Transgenic
Obesity/genetics*
Phenotype
Receptors, Cell Surface*
Receptors, Leptin


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