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Type of publication: Journal Article
Type of document: Full Paper

Year: 2000

Authors: Steinborn, R; Schinogl, P; Zakhartchenko, V; Achmann, R; Schernthaner, W; Stojkovic, M; Wolf, E; Müller, M; Brem, G

Title: Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and adult cell cloning.

Source: Nat Genet. 2000; 25(3):255-257

Authors Vetmeduni Vienna:

Brem Gottfried
Müller Mathias
Steinborn Ralf

Vetmed Research Units
Institute of Animal Breeding and Genetics

Mammals have been cloned from adult donor cells. Here we report the first cases of mitochondrial DNA (mtDNA) heteroplasmy in adult mammalian clones generated from fetal and adult donor cells. The heteroplasmic clones included a healthy cattle equivalent of the sheep Dolly, for which a lack of heteroplasmy was reported.

Keywords Pubmed: Animals
Cells, Cultured
Cloning, Organism*
DNA, Mitochondrial*
Epithelial Cells/cytology
Genetic Variation*

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