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Type of publication: Journal Article
Type of document: Full Paper

Year: 2000

Authors: Harr, B; Zangerl, B; Schlötterer, C

Title: Removal of microsatellite interruptions by DNA replication slippage: phylogenetic evidence from Drosophila.

Source: Mol Biol Evol. 2000; 17(7):1001-1009

Authors Vetmeduni Vienna:

Schlötterer Christian

Vetmed Research Units
Institute of Animal Breeding and Genetics

Microsatellites are tandem repetitions of short (1-6 bp) motifs. It is widely assumed that microsatellites degenerate through the accumulation of base substitutions in the repeat array. Using a phylogenetic framework, we studied the evolutionary dynamics of interruptions in three Drosophila microsatellite loci. For all three loci, we show that the interruptions in a microsatellite can be lost, resulting in a longer uninterrupted microsatellite stretch. These results indicate that mutations in the microsatellite array do not necessarily lead to decay but may represent only a transition state during the evolution of a microsatellite. Most likely, this purification of interrupted microsatellites is caused by DNA replication slippage.

Keywords Pubmed: Animals
Base Sequence
DNA Replication*
Molecular Sequence Data
Sequence Homology, Nucleic Acid
Species Specificity

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