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Type of publication: Journal Article
Type of document: Full Paper

Year: 2000

Authors: Schlötterer, C; Harr, B

Title: Drosophila virilis has long and highly polymorphic microsatellites.

Source: Mol Biol Evol. 2000; 17(11):1641-1646


Authors Vetmeduni Vienna:

Schlötterer Christian

Vetmed Research Units
Institute of Animal Breeding and Genetics


Abstract:
Comparative genomics is a powerful approach to inference of the dynamics of genome evolution. Most information about the evolution of microsatellites in the genus Drosophila has been obtained from Drosophila melanogaster. For comparison, we collected microsatellite data for the distantly related species Drosophila virilis. Screening about 0.5 Mb of nonredundant genomic sequence from GenBank, we identified 239 dinucleotide microsatellites. On average, D. virilis dinucleotides were significantly longer than D. melanogaster microsatellites (7.69 repeats vs. 6.75 repeats). Similarly, direct cloning of microsatellites resulted in a higher mean repeat number in D. virilis than in D. melanogaster (12.7 repeats vs. 12.2 repeats). Characterization of 11 microsatellite loci mapping to division 40-49 on the fourth chromosome of D. virilis indicated that D. virilis microsatellites are more variable than those of D. melanogaster.

Keywords Pubmed: Animals
DNA/genetics
Databases, Factual
Drosophila/genetics*
Drosophila melanogaster/genetics
Evolution, Molecular
Genetic Variation
Microsatellite Repeats/genetics*
Polymorphism, Genetic
Species Specificity


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