Mayr, B; Wilhelm, B; Reifinger, M; Brem, G
Absence of p21 WAF1 and p27 kip1 gene mutations in various feline tumours.
Vet Res Commun. 2000; 24(2):115-124
Authors Vetmeduni Vienna:
Vetmed Research Units
Institute of Animal Breeding and Genetics
Institute of Pathology
The coding regions of tumour suppressor and cell cycle regulatory genes p21 WAF1 and p27 Kip1 were investigated in 101 feline tumours of various types. No damaging mutations were present in the analysed areas of the genes.
Adenocarcinoma/genetics Adenocarcinoma/veterinary Amino Acid Sequence Animals Base Sequence Carcinoma, Basal Cell/genetics Carcinoma, Basal Cell/veterinary Carcinoma, Squamous Cell/genetics Carcinoma, Squamous Cell/veterinary Cat Diseases/genetics* Cats Cell Cycle Proteins* Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclins/genetics* DNA Primers/chemistry DNA, Neoplasm/chemistry DNA, Neoplasm/genetics DNA, Neoplasm/isolation & purification Female Fibrosarcoma/genetics Fibrosarcoma/veterinary Histiocytoma, Benign Fibrous/genetics Histiocytoma, Benign Fibrous/veterinary Mammary Neoplasms, Animal/genetics Melanoma/genetics Melanoma/veterinary Microtubule-Associated Proteins/genetics* Molecular Sequence Data Mutation Neoplasms/genetics Neoplasms/veterinary* Pancreatic Neoplasms/genetics Pancreatic Neoplasms/veterinary Polymerase Chain Reaction/veterinary Sequence Analysis, DNA Tumor Suppressor Proteins*