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Publication type: Journal Article
Document type: Full Paper

Year: 2000

Author(s): Mayr, B; Resch, S; Hepperle, S; Brem, G; Reifinger, M; Schaffner, G

Title: Comparative studies in the promoter and exon 1 regions of tumour suppressor p53 in several mammalian species: absence of mutations in a panel of spontaneous domestic animal tumours.

Source: J Vet Med A Physiol Pathol Clin Med. 2000; 47(10):593-597



Authors Vetmeduni Vienna:

Brem Gottfried

Vetmed Research Units
Institute of Animal Breeding and Genetics


Abstract:
Tumour suppressor p53 is critical in a broad panel of tumour types in human, mouse and other mammals. Regions of the promoter and exon 1 play an important role in expression of p53. In the present study, the DNA sequences of promoter and exon 1 regions of four domestic animal species (dog, cat, horse and cattle) are determined and compared with experimental rodents (mouse, rat and hamster) and man. A broad panel of tumour types have been investigated for mutations in this regulatory area in 90 canine, 136 feline, 25 equine and 10 bovine patients. No mutation was detected in any of the tumours analysed.

Keywords Pubmed: Animals
Animals, Domestic*
Cats
Cattle
Dogs
Exons
Genes, p53*
Horses
Humans
Mutation
Neoplasms/genetics
Neoplasms/veterinary*
Promoter Regions, Genetic
Rodentia
Sequence Analysis, DNA/veterinary
Species Specificity


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