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Selected Publication:

Publication type: Journal Article
Document type: Full Paper

Year: 2008

Author(s): Kixmöller, M; Ritzmann, M; Eddicks, M; Saalmüller, A; Elbers, K; Fachinger, V

Title: Reduction of PMWS-associated clinical signs and co-infections by vaccination against PCV2.

Source: Vaccine. 2008; 26(27-28):3443-3451



Authors Vetmeduni Vienna:

Ritzmann Mathias
Saalmüller Armin

Vetmed Research Units
Institute of Immunology


Abstract:
The effects of a single-dose recombinant Porcine circovirus type 2 (PCV2) open reading frame 2 (ORF2) subunit vaccine were studied in a post-weaning multisystemic wasting syndrome (PMWS)-affected pig herd. A total of 1519 3-week-old piglets were allocated randomly into two treatment groups and either vaccinated against PCV2 or treated with a placebo. Study animals were followed from the time of vaccination until the end of finishing. Onset of PCV2 viraemia and clinical signs of PMWS (wasting, cough, dyspnoea, pallor and lethargy) were observed when animals were approximately 9-10 weeks old. Compared to placebo-treated animals, vaccinated animals had a significantly reduced PCV2 viral load and duration of viraemia (p < 0.0001). This reduction in viraemia was not affected by the level of maternal anti-PCV2 antibodies present at the time of vaccination. During the period of viraemia (10-26 weeks of age) vaccinated animals exhibited a 53% reduction in mortality rate (p = 0.0010), a 4.84 kg higher body weight gain (p < 0.0001) and a significant reduction in clinical signs (p < or = 0.0004). Furthermore, lung samples of vaccinated animals had a considerably reduced number of co-infections with PRRSV and Mycoplasma hyorhinis than lung samples of placebo-treated animals. These data indicate that vaccination against PCV2 alone protects pigs from clinical signs and co-infections associated with PMWS.

Keywords Pubmed: Animals
Body Weight
Circoviridae Infections/immunology*
Circoviridae Infections/physiopathology
Circoviridae Infections/prevention & control*
Circovirus/genetics
Circovirus/immunology*
Cough/prevention & control
Dyspnea/prevention & control
Lethargy/prevention & control
Lung/microbiology
Lung/virology
Mycoplasma hyorhinis/isolation & purification
Pallor/prevention & control
Placebos/administration & dosage
Porcine Postweaning Multisystemic Wasting Syndrome/immunology*
Porcine Postweaning Multisystemic Wasting Syndrome/physiopathology
Porcine Postweaning Multisystemic Wasting Syndrome/prevention & control*
Porcine respiratory and reproductive syndrome virus/isolation & purification
Survival Analysis
Swine
Vaccines, Subunit/immunology
Vaccines, Synthetic/immunology
Viral Load
Viral Proteins/genetics
Viral Proteins/immunology
Viral Vaccines/immunology*
Viremia/prevention & control


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