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Type of publication: Journal Article
Type of document: Full Paper

Year: 2008

Authors: Sasse, P; Malan, D; Fleischmann, M; Roell, W; Gustafsson, E; Bostani, T; Fan, Y; Kolbe, T; Breitbach, M; Addicks, K; Welz, A; Brem, G; Hescheler, J; Aszodi, A; Costell, M; Bloch, W; Fleischmann, BK

Title: Perlecan is critical for heart stability.

Source: Cardiovasc Res. 2008; 80(3):435-444

Authors Vetmeduni Vienna:

Brem Gottfried
Kolbe Thomas

Perlecan is a heparansulfate proteoglycan found in basement membranes, cartilage, and several mesenchymal tissues that form during development, tumour growth, and tissue repair. Loss-of-function mutations in the perlecan gene in mice are associated with embryonic lethality caused primarily by cardiac abnormalities probably due to hemopericards. The aim of the present study was to investigate the mechanism underlying the early embryonic lethality and the pathophysiological relevance of perlecan for heart function.

Keywords Pubmed: Animals
Basement Membrane/physiopathology
Cell Communication/physiology
Cell Differentiation/physiology
Cells, Cultured
Disease Models, Animal
Embryonic Stem Cells/cytology
Embryonic Stem Cells/metabolism
Heparan Sulfate Proteoglycans/genetics
Heparan Sulfate Proteoglycans/metabolism*
Mice, Inbred C57BL
Mice, Transgenic
Myocardial Infarction/metabolism
Myocardial Infarction/pathology
Myocardial Infarction/physiopathology
Myocytes, Cardiac/metabolism
Myocytes, Cardiac/pathology
Myocytes, Cardiac/transplantation
Patch-Clamp Techniques
Ventricular Function, Left/physiology*

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