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Publication type: Journal Article
Document type: Full Paper

Year: 2008

Author(s): Sasse, P; Malan, D; Fleischmann, M; Roell, W; Gustafsson, E; Bostani, T; Fan, Y; Kolbe, T; Breitbach, M; Addicks, K; Welz, A; Brem, G; Hescheler, J; Aszodi, A; Costell, M; Bloch, W; Fleischmann, BK

Title: Perlecan is critical for heart stability.

Source: Cardiovasc Res. 2008; 80(3):435-444



Authors Vetmeduni Vienna:

Brem Gottfried
Kolbe Thomas


Abstract:
Perlecan is a heparansulfate proteoglycan found in basement membranes, cartilage, and several mesenchymal tissues that form during development, tumour growth, and tissue repair. Loss-of-function mutations in the perlecan gene in mice are associated with embryonic lethality caused primarily by cardiac abnormalities probably due to hemopericards. The aim of the present study was to investigate the mechanism underlying the early embryonic lethality and the pathophysiological relevance of perlecan for heart function.

Keywords Pubmed: Animals
Basement Membrane/physiopathology
Cell Communication/physiology
Cell Differentiation/physiology
Cells, Cultured
Disease Models, Animal
Embryonic Stem Cells/cytology
Embryonic Stem Cells/metabolism
Female
Heart/embryology*
Heart/physiology*
Heparan Sulfate Proteoglycans/genetics
Heparan Sulfate Proteoglycans/metabolism*
Mice
Mice, Inbred C57BL
Mice, Transgenic
Myocardial Infarction/metabolism
Myocardial Infarction/pathology
Myocardial Infarction/physiopathology
Myocytes, Cardiac/metabolism
Myocytes, Cardiac/pathology
Myocytes, Cardiac/transplantation
Patch-Clamp Techniques
Ventricular Function, Left/physiology*


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