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Publication type: Journal Article
Document type: Full Paper

Year: 2008

Author(s): Schneider, A; Reichart, U; Gerner, W; Kolbe, T; Saalmüller, A; Müller, M

Title: Selective contribution of Tyk2 to cell activation by lipopolysaccharide.

Source: FEBS Lett. 2008; 582(25-26):3681-3686



Authors Vetmeduni Vienna:

Gerner Wilhelm
Kolbe Thomas
Müller Mathias
Reichart Ursula
Saalmüller Armin
Schneider Andrea

Vetmed Research Units
Institute of Animal Breeding and Genetics
Institute of Immunology
Institute of Laboratory Animal Science


Abstract:
Tyk2 deficient mice show a markedly reduced susceptibility to lipopolysaccharide (LPS) induced shock and a partial impairment of IL-12 and interferon (IFN) signals. To examine the underlying mechanisms, we analysed the activation of peritoneal macrophages (PMPhis) and spleen cells after LPS challenge. In PMPhis and spleen cells the contribution of Tyk2 to the induction of the T-cell co-stimulatory molecules CD86, CD40 and MHC II was small or insignificant. By contrast, induced expression of the early activation marker CD69 on PMPhis and splenic cell populations required type I interferons (IFN-I) and Tyk2. The data suggest a selective contribution of Tyk2 to the activation of inflammation-relevant cell types by LPS.

Keywords Pubmed: Animals
Antigens, CD/immunology
Antigens, CD86/immunology
Antigens, Differentiation, T-Lymphocyte/immunology
Interferon Type I/immunology
Interferons/immunology
Interleukin-12/immunology
Lectins, C-Type
Lipopolysaccharides/immunology*
Lymphocyte Activation*/genetics
Macrophage Activation*/genetics
Macrophages, Peritoneal/enzymology
Macrophages, Peritoneal/immunology
Male
Mice
Mice, Mutant Strains
Receptor, Interferon alpha-beta/immunology
Spleen/cytology
Spleen/immunology
T-Lymphocytes/enzymology
T-Lymphocytes/immunology
TYK2 Kinase/genetics
TYK2 Kinase/physiology*
Up-Regulation


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