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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2008

Authors: Mueller, M; Lukas, B; Novak, J; Simoncini, T; Genazzani, AR; Jungbauer, A

Title: Oregano: a source for peroxisome proliferator-activated receptor gamma antagonists.

Source: J Agric Food Chem. 2008; 56(24):11621-11630

Authors Vetmeduni Vienna:

Lukas Brigitte
Novak Johannes

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds

Peroxisome proliferator-activated receptors (PPARs) are drug targets for several perturbations of metabolic syndrome, defined as the coexistence of obesity, hyperglycemia, hypertension, and hyper/dyslipidemia. In this study, PPAR activation by oregano (e.g., Origanum vulgare) and its components was tested. Oregano extracts bind but do not transactivate PPARgamma, and binding affinity differs among different oregano extracts. The extracts contain PPARgamma antagonists (e.g., quercetin, luteolin, rosmarinic acid, and diosmetin), selective PPARgamma modulators (e.g., naringenin and apigenin), and PPARgamma agonists (e.g., biochanin A). Oregano extract and isolated compounds in the extract antagonize rosiglitazone-mediated DRIP205/TRAP220 recruitment to PPARgamma, pointing to oregano extracts as putative food supplements for weight reduction. Rosmarinic acid and biochanin A, PPARalpha agonists, may ameliorate the lipid profile. By endothelial nitric oxide synthase activation, oregano extract could prevent atherosclerosis. The results warrant further investigation of oregano extract for its potential to prevent and ameliorate metabolic syndrome and its complications.

Keywords Pubmed: Animals
Cells, Cultured
Endothelial Cells/drug effects
Endothelial Cells/metabolism
NIH 3T3 Cells
Nitric Oxide Synthase/metabolism
PPAR gamma/antagonists & inhibitors*
PPAR gamma/metabolism
Plant Extracts/chemistry
Plant Extracts/pharmacology*

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