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Publication type: Journal Article
Document type: Full Paper

Year: 1993

Author(s): Masu, Y; Wolf, E; Holtmann, B; Sendtner, M; Brem, G; Thoenen, H

Title: Disruption of the CNTF gene results in motor neuron degeneration.

Source: Nature (365), 6441 27-32.

Authors Vetmeduni Vienna:

Brem Gottfried

CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.

Keywords Pubmed: Aging - physiology : Animals - physiology : Base Sequence - physiology : Cells, Cultured - physiology : Ciliary Neurotrophic Factor - physiology : Cloning, Molecular - physiology : DNA, Single-Stranded - physiology : Gene Expression Regulation - physiology : Male - physiology : Mice - physiology : Mice, Inbred C57BL - physiology : Mice, Mutant Strains - physiology : Molecular Sequence Data - physiology : Motor Neurons - cytology : Muscles - physiopathology : Nerve Degeneration - physiopathology : Nerve Tissue Proteins - genetics : Spinal Cord - cytology

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