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Selected Publication:

Publication type: Journal Article
Document type: Review

Year: 1992

Author(s): Wanke, R; Wolf, E; Hermanns, W; Folger, S; Buchm├╝ller, T; Brem, G

Title: The GH-transgenic mouse as an experimental model for growth research: clinical and pathological studies.

Source: INTERNATIONAL SYMP ON ENDOCRINOLOGY AND DEVELOPMENT : BASIC AND CLINICAL ASPECTS, ATHENS, GREECE, OCT 12-14, 1990. Horm Res (37 Suppl 3) 74-87.



Authors Vetmeduni Vienna:

Brem Gottfried


Abstract:
The objectives and the methodology of mammalian gene transfer are discussed and findings in growth hormone (GH) transgenic mice are reported to illustrate the potential offered by genetically designed animal models for investigations in various areas of biomedical research. Transgenic mice expressing hybrid genes composed of either human or bovine GH coding sequences fused to the mouse metallothionein I promoter show high serum levels of heterologous GH, increased growth rates and final adult size, decreased life expectancy and a variety of pathological changes.

Keywords Pubmed: Animals - : Female - : Gene Expression - : Growth - genetics : Growth Hormone - blood : Male - blood : Mice - blood : Mice, Transgenic - blood : Models, Biological - blood : Promoter Regions, Genetic - blood : Transfection - blood

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