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Publication type: Journal Article
Document type: Full Paper

Year: 2010

Author(s): Morina, R; Knorr, C; Haase, B; Leeb, T; Seuberlich, T; Zurbriggen, A; Brem, G; Sch├╝tz, E; Brenig, B

Title: Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility.

Source: Anim Genet. 2010; 41(1):85-88



Authors Vetmeduni Vienna:

Brem Gottfried

Vetmed Research Units
Institute of Animal Breeding and Genetics


Abstract:
Endogenous prion proteins (PrP) play the central role in the pathogenesis of transmissible spongiform encephalopathies. The carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) promotes the conversion of the cellular PrP(C) into the pathogenic PrP(d). Six sequence variants within the CHST8 gene were identified by comparative sequencing and genotyped for a sample of 623 animals comprising bovine spongiform encephalopathy (BSE)-affected and healthy control cows representing German Fleckvieh (German Simmental), German Holstein (Holstein-Friesian) and Brown Swiss. Significant differences in the allele, genotype and haplotype frequencies between BSE-affected and healthy cows indicate an association of sequence variant g.37254017G>T with the development of the disease in Brown Swiss cattle.

Keywords Pubmed: Animals
Cattle/genetics*
Encephalopathy, Bovine Spongiform/genetics*
Encephalopathy, Bovine Spongiform/metabolism
Genetic Predisposition to Disease*
PrPC Proteins/metabolism
Sulfotransferases/genetics*
Sulfotransferases/metabolism


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