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Selected Publication:

Publication type: Journal Article
Document type: Full Paper

Year: 2010

Author(s): Reiczigel, J; Brugger, K; Rubel, F; Solymosi, N; Lang, Z

Title: Bayesian analysis of a dynamical model for the spread of the Usutu virus.

Source: Stoch Environ Res Risk Assess (24), 3 455-462.



Authors Vetmeduni Vienna:

Brugger Katharina
Reiczigel Jenö
Rubel Franz

Vetmed Research Units
Institute of Food Safety, Food Technology and Veterinary Public Health, Unit of Veterinary Public Health and Epidemiology


Abstract:
The Usutu virus is an arbovirus transmitted by mosquitoes and causing disease in birds. The virus was detected in Austria for the first time in 2001, while a major outbreak occurred in 2003. Rubel et al. (2008) developed a nine-compartment deterministic SEIR model to explain the spread of the disease. We extended this to a hierarchical Bayes model assuming random variation in temperature data, in reproduction data of birds, and in the number of birds found to be infected. The model was implemented in R, combined with the FORTRAN subroutine for the original deterministic model. Analysis was made by MCMC using a random walk Metropolis scheme. Posterior means, medians, and credible intervals were calculated for the parameters. The hierarchical Bayes approach proved to be fruitful in extending the deterministic model into a stochastic one. It allowed for Bayesian point and interval estimation and quantification of uncertainty of predictions. The analysis revealed that some model parameters were not identifiable; therefore we kept constant some of them and analyzed others conditional on them. Identifiability problems are common in models aiming to mirror the mechanism of the process, since parameters with natural interpretation are likely to exhibit interrelationships. This study illustrated that Bayesian modeling combined with conditional analysis may help in those cases. Its application to the Usutu model improved model fit and revealed the structure of interdependencies between model parameters: it demonstrated that determining some of them experimentally would enable estimation of the others, except one of them, from available data.


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