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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2010

Authors: Musteanu, M; Blaas, L; Mair, M; Schlederer, M; Bilban, M; Tauber, S; Esterbauer, H; Mueller, M; Casanova, E; Kenner, L; Poli, V; Eferl, R

Title: Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice.

Source: Gastroenterology. 2010; 138(3):1003-11.e1-5



Authors Vetmeduni Vienna:

Kenner Lukas
Müller Mathias

Vetmed Research Units
Institute of Animal Breeding and Genetics


Abstract:
The transcription factor signal transducer and activator of transcription 3 (Stat3) has been considered to promote progression and metastasis of intestinal cancers.

Keywords Pubmed: Adenomatous Polyposis Coli/genetics
Adenomatous Polyposis Coli/metabolism*
Adenomatous Polyposis Coli/pathology
Animals
Carcinoembryonic Antigen/metabolism
Carcinoma/genetics
Carcinoma/metabolism*
Carcinoma/pathology
Cell Proliferation
Cell Transformation, Neoplastic/genetics
Cell Transformation, Neoplastic/metabolism*
Cell Transformation, Neoplastic/pathology
Colorectal Neoplasms/genetics
Colorectal Neoplasms/metabolism*
Colorectal Neoplasms/pathology
Disease Models, Animal
Disease Progression
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genes, APC*
Intestinal Mucosa/metabolism
Intestinal Mucosa/pathology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Neoplasm Invasiveness
STAT3 Transcription Factor/deficiency
STAT3 Transcription Factor/genetics
STAT3 Transcription Factor/metabolism*
Signal Transduction*/genetics
Time Factors
beta Catenin/metabolism


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