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Type of publication: Journal Article
Type of document: Full Paper

Year: 2010

Authors: Hofmann, E; Reichart, U; Gausterer, C; Guelly, C; Meijer, D; Müller, M; Strobl, B

Title: Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses.

Source: BMC Cell Biol. 2010; 11:61

Authors Vetmeduni Vienna:

Hofmann Elisabeth
Müller Mathias
Reichart Ursula
Strobl Birgit

Vetmed Research Units
Institute of Animal Breeding and Genetics

Octamer-binding factor 6 (Oct-6, Pou3f1, SCIP, Tst-1) is a transcription factor of the Pit-Oct-Unc (POU) family. POU proteins regulate key developmental processes and have been identified from a diverse range of species. Oct-6 expression is described to be confined to the developing brain, Schwann cells, oligodendrocyte precursors, testes, and skin. Its function is primarily characterised in Schwann cells, where it is required for correctly timed transition to the myelinating state. In the present study, we report that Oct-6 is an interferon (IFN)-inducible protein and show for the first time expression in murine fibroblasts and macrophages.

Keywords Pubmed: Animals
Fibroblasts/drug effects
Immunity, Innate/genetics
Macrophages/drug effects
Mice, Knockout
Microarray Analysis
Octamer Transcription Factor-6/genetics
Octamer Transcription Factor-6/metabolism*
Protein-Serine-Threonine Kinases/biosynthesis
Protein-Serine-Threonine Kinases/genetics
RNA, Double-Stranded/pharmacology
RNA, Viral/pharmacology
Ribonucleoprotein, U7 Small Nuclear/biosynthesis
Ribonucleoprotein, U7 Small Nuclear/genetics
STAT1 Transcription Factor/genetics
STAT1 Transcription Factor/metabolism
Transcriptional Activation/drug effects
Virus Diseases/genetics
Virus Diseases/immunology
Virus Diseases/metabolism*

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