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Type of publication: Journal Article
Type of document: Case Report

Year: 2010

Authors: Zeugswetter, F; Kleiter, M; Wolfesberger, B; Schwendenwein, I; Miller, I

Title: Elevated fructosamine concentrations caused by IgA paraproteinemia in two dogs.

Source: J Vet Sci. 2010; 11(4):359-361

Authors Vetmeduni Vienna:

Kleiter Miriam
Miller Ingrid
Schwendenwein Ilse
Wolfesberger Birgitt
Zeugswetter Florian

Vetmed Research Units
Clinical Pathology Platform
University Clinic for Small Animals, Clinical Unit of Internal Medicine Small Animals
Institute for Medical Biochemistry

An 8-year-old male Austrian Pinscher and a 14-year-old male Golden Retriever were presented for evaluation due to unexplainable high fructosamine values despite euglycemia and epistaxis in combination with polydipsia/polyuria, respectively. Blood analysis revealed severe hyperglobulinemia, hypoalbuminemia and markedly elevated fructosamine concentrations in both dogs. Multiple myeloma with IgA-monoclonal gammopathy was diagnosed by serum and urine electrophoresis including immunodetection with an anti-dog IgA antibody and bone marrow aspirations. Diabetes mellitus was excluded by repeated plasma and urine glucose measurements. Fructosamine values were positively correlated with globulin, but negatively correlated with albumin concentrations. These cases suggest that, as in human patients, monoclonal IgA gammopathy should be considered as a possible differential diagnosis for dogs with high fructosamine concentrations.

Keywords Pubmed: Animals
Blood Proteins/analysis
Dog Diseases/blood*
Dog Diseases/drug therapy
Immunoglobulin A/metabolism*
Melphalan/therapeutic use
Multiple Myeloma/complications
Multiple Myeloma/drug therapy
Multiple Myeloma/veterinary*
Myeloablative Agonists/therapeutic use
Paraproteinemias/drug therapy

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