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Type of publication: Journal Article
Type of document: Full Paper

Year: 2011

Authors: Gad, A; Besenfelder, U; Rings, F; Ghanem, N; Salilew-Wondim, D; Hossain, MM; Tesfaye, D; Lonergan, P; Becker, A; Cinar, U; Schellander, K; Havlicek, V; Hölker, M

Title: Effect of reproductive tract environment following controlled ovarian hyperstimulation treatment on embryo development and global transcriptome profile of blastocysts: implications for animal breeding and human assisted reproduction.

Source: Hum Reprod. 2011; 26(7):1693-1707

Authors Vetmeduni Vienna:

Besenfelder Urban
Havlicek Vitezslav

Vetmed Research Units
Institute of Animal Breeding and Genetics

In mammals, the reproductive tract plays a crucial role in the success of early reproductive events and provides an optimal microenvironment for early embryonic development. However, changes in the reproductive tract environment associated with controlled ovarian hyperstimulation and the influence on the embryo transcriptome profile have not been investigated. Therefore, we investigated differences in the development rate and the transcriptome profile of bovine blastocysts developing in the reproductive tract of unstimulated or superovulated heifers.

Keywords Pubmed: Animals
Cluster Analysis
Electron Transport/genetics
Electron Transport Complex III/genetics
Electron Transport Complex III/metabolism
Embryo Transfer
Embryonic Development/drug effects*
Embryonic Development/genetics
Embryonic Development/physiology
Gene Expression Profiling
Insemination, Artificial
Oviducts/drug effects*
Ovulation Induction*
Oxidative Phosphorylation
Uterus/drug effects*

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