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Selected Publication:

Publication type: Journal Article
Document type: Review

Year: 2012

Author(s): Käser, T; Gerner, W; Mair, K; Hammer, SE; Patzl, M; Saalmüller, A

Title: Current knowledge on porcine regulatory T cells.

Source: Vet Immunol Immunopathol. 2012; 148(1-2):136-138

Authors Vetmeduni Vienna:

Gerner Wilhelm
Hammer Sabina
Käser Tobias
Mair Kerstin
Patzl Martina
Saalmüller Armin

Vetmed Research Units
Institute of Immunology

Regulatory T cells (Tregs) are known in humans and mice from last 15 years, and several studies led to a detailed knowledge on their phenotype, functions, and role in various immune reactions. In swine, the existence of Tregs was first demonstrated in 2008 and research is still at the beginning. Nevertheless, basic information regarding phenotype, mechanisms and targets of suppression, as well as implications in transplantation and some diseases are available. Purpose of this review is to give a brief summary of the current knowledge about porcine Tregs.

Keywords Pubmed: Animals
Forkhead Transcription Factors/immunology
Immune Tolerance/immunology
T-Lymphocytes, Regulatory/immunology*

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