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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2012

Authors: Siller-Matula, JM; Miller, I; Gemeiner, M; Plasenzotti, R; Bayer, G; Mesteri, I; Fabry, A; Petroczi, K; Nöbauer, K; Razzazi-Fazeli, E; Planchon, S; Renaut, J; Quehenberger, P; Selzer, E; Jilma, B

Title: Continuous thrombin infusion leads to a bleeding phenotype in sheep.

Source: Thromb Res. 2012; 130(2):226-236



Authors Vetmeduni Vienna:

Gemeiner Manfred
Miller Ingrid
Nöbauer Katharina
Razzazi-Fazeli Ebrahim

Vetmed Research Units
Institute for Medical Biochemistry
VetCore


Abstract:
In addition to a recognized role in the coagulation cascade and haemostasis, thrombin is known to have multiple functions. We aimed to establish an ovine model to study thrombin effects in vivo.

Keywords Pubmed: Administration, Intravenous
Amino Acid Sequence
Animals
Blood Coagulation/drug effects*
Blood Platelets/cytology
Blood Platelets/drug effects
Blood Proteins/analysis
Blood Proteins/metabolism
Fibrinogen/analysis
Fibrinogen/metabolism
Hemorrhage/chemically induced*
Hemorrhage/pathology
Hemostatics/administration & dosage
Hemostatics/adverse effects*
Lung/drug effects
Lung/pathology
Mass Spectrometry
Molecular Sequence Data
Platelet Count
Platelet Function Tests
Proteomics
Sheep/blood*
Sheep/metabolism
Thrombelastography
Thrombin/administration & dosage
Thrombin/adverse effects*


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