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Selected Publication:

Publication type: Journal Article
Document type: Full Paper

Year: 2012

Author(s): Khol-Parisini, A; Hellweg, P; Razzazi-Fazeli, E; Saalmüller, A; Strasser, A; Tichy, A; Zenteke, J

Title: Highly deoxynivalenol contaminated oats and immune function in horses.

Source: Arch Anim Nutr. 2012; 66(2):149-161



Authors Vetmeduni Vienna:

Khol Annabella
Razzazi-Fazeli Ebrahim
Saalmüller Armin
Strasser Alois
Tichy Alexander
Zentek Jürgen

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds
Institute of Immunology
Platform Bioinformatics and Biostatistics
Institute of Physiology, Pathohysiology and Biophysics, Unit of Physiology, Pathophysiology, and Experimental Endocrinology


Abstract:
The aim of the present study was to investigate the impact of deoxynivalenol (DON) on cellular and humoral immune parameters in horses. A feeding trial using naturally contaminated oats with high (20.2 mg/kg) and low (0.49 mg/kg) levels of DON was conducted. Two groups of five mares were fed 2 kg oats daily with high or low DON levels for two weeks, using a crossover design with a three-week wash-out period. No adverse effects on general health were observed. Only minor diet-related changes in differential blood counts and serum biochemistry were noted. Serum haptoglobin concentration was significantly elevated after feeding DON (p = 0.04). Lymphocyte subsets (CD4+ CD8+, CD2+, CD21+, MHCII+) and lymphocyte proliferation data (concanavalin A, phytohemagglutinin, pokeweed mitogen) were not different between feeding-groups. It can be concluded that daily DON intakes as high as 6.9 to 9.5 mg/100 kg BW appear to have no major impact on the measured immune response of horses, indicating that this species has a high tolerance for DON.

Keywords Pubmed: Animal Feed/analysis*
Animals
Avena sativa/chemistry*
Cross-Over Studies
Diet/veterinary
Female
Food Contamination/analysis*
Horse Diseases/chemically induced*
Horse Diseases/immunology
Horses
Immunity, Cellular/drug effects
Immunity, Humoral/drug effects
Trichothecenes/chemistry*
Trichothecenes/toxicity*


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