Type of publication:
Type of document:
Hadzijusufovic, E; Peter, B; Herrmann, H; Rülicke, T; Cerny-Reiterer, S; Schuch, K; Kenner, L; Thaiwong, T; Yuzbasiyan-Gurkan, V; Pickl, WF; Willmann, M; Valent, P
NI-1: a novel canine mastocytoma model for studying drug resistance and IgER-dependent mast cell activation.
Allergy. 2012; 67(7):858-868
Authors Vetmeduni Vienna:
Vetmed Research Units
University Clinic for Small Animals, Clinical Unit of Internal Medicine Small Animals
Institut für In-vivo und In-vitro-Modelle
Advanced mast cell (MC) disorders are characterized by uncontrolled growth of neoplastic MC in various organs, mediator-related symptoms, and a poor prognosis. Kit mutations supposedly contribute to abnormal growth and drug resistance in these patients.
Animals Antineoplastic Agents/pharmacology Apoptosis/drug effects Caspase 3/metabolism Cell Line, Tumor Cell Proliferation/drug effects Dogs Drug Resistance, Neoplasm* Enzyme Activation/drug effects Histamine Release Immunophenotyping Male Mast Cells/drug effects Mast Cells/metabolism Mast Cells/pathology* Mastocytoma/genetics Mastocytoma/immunology* Mastocytoma/metabolism* Mice Mice, Inbred NOD Mice, SCID Mutation Phenotype Proto-Oncogene Proteins c-kit/genetics Receptors, IgE/immunology Receptors, IgE/metabolism*