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Type of publication: Journal Article
Type of document: Full Paper

Year: 2012

Authors: Hadzijusufovic, E; Peter, B; Herrmann, H; Rülicke, T; Cerny-Reiterer, S; Schuch, K; Kenner, L; Thaiwong, T; Yuzbasiyan-Gurkan, V; Pickl, WF; Willmann, M; Valent, P

Title: NI-1: a novel canine mastocytoma model for studying drug resistance and IgER-dependent mast cell activation.

Source: Allergy. 2012; 67(7):858-868



Authors Vetmeduni Vienna:

Hadzijusufovic Emir
Kenner Lukas
Peter Barbara
Rülicke Thomas
Willmann Michael

Vetmed Research Units
University Clinic for Small Animals, Clinical Unit of Internal Medicine Small Animals
Institut für In-vivo und In-vitro-Modelle


Abstract:
Advanced mast cell (MC) disorders are characterized by uncontrolled growth of neoplastic MC in various organs, mediator-related symptoms, and a poor prognosis. Kit mutations supposedly contribute to abnormal growth and drug resistance in these patients.

Keywords Pubmed: Animals
Antineoplastic Agents/pharmacology
Apoptosis/drug effects
Caspase 3/metabolism
Cell Line, Tumor
Cell Proliferation/drug effects
Dogs
Drug Resistance, Neoplasm*
Enzyme Activation/drug effects
Histamine Release
Immunophenotyping
Male
Mast Cells/drug effects
Mast Cells/metabolism
Mast Cells/pathology*
Mastocytoma/genetics
Mastocytoma/immunology*
Mastocytoma/metabolism*
Mice
Mice, Inbred NOD
Mice, SCID
Mutation
Phenotype
Proto-Oncogene Proteins c-kit/genetics
Receptors, IgE/immunology
Receptors, IgE/metabolism*


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