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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2012

Authors: Musteanu, M; Blaas, L; Zenz, R; Svinka, J; Hoffmann, T; Grabner, B; Schramek, D; Kantner, HP; Müller, M; Kolbe, T; Rülicke, T; Moriggl, R; Kenner, L; Stoiber, D; Penninger, JM; Popper, H; Casanova, E; Eferl, R

Title: A mouse model to identify cooperating signaling pathways in cancer.

Source: Nat Methods. 2012; 9(9):897-900

Authors Vetmeduni Vienna:

Kenner Lukas
Kolbe Thomas
Moriggl Richard
Müller Mathias
Rülicke Thomas

Vetmed Research Units
Biomodels Austria
Institut für In-vivo und In-vitro-Modelle
Institute of Animal Breeding and Genetics

We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ("hits") that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.

Keywords Pubmed: Animals
Disease Models, Animal*
Lung Neoplasms/genetics
Lung Neoplasms/metabolism*
Lung Neoplasms/pathology
Mice, Transgenic
Neoplasms, Experimental/genetics
Neoplasms, Experimental/metabolism*
Neoplasms, Experimental/pathology
Oncogene Protein p21(ras)/genetics
Oncogene Protein p21(ras)/metabolism*
Pancreatic Neoplasms/genetics
Pancreatic Neoplasms/metabolism
Pancreatic Neoplasms/pathology
Signal Transduction*/genetics

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