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Publication type: Journal Article
Document type: Full Paper

Year: 1998

Author(s): Pauly, T; König, M; Thiel, HJ; Saalmüller, A

Title: Infection with classical swine fever virus: effects on phenotype and immune responsiveness of porcine T lymphocytes.

Source: J Gen Virol (79 ( Pt 1)) 31-40.



Authors Vetmeduni Vienna:

Saalmüller Armin


Abstract:
T lymphocytes obtained from pigs infected with a lethal dose of classical swine fever virus were analysed for phenotypic changes in the composition of T-cell subpopulations and for alterations in their immune responsiveness in vitro during the course of disease. Viral antigen detected in all subpopulations and the selective depletion of CD4- CD8- gamma/delta T cells showed that peripheral blood T lymphocytes were affected in the terminal stage (14-19 days post-infection) of classical swine fever whereas no implications for T lymphocytes were obvious during the first 10 days after infection. Furthermore, a depletion of CD1+ CD4+ CD8+ "common thymocytes" was characteristic for the infected animals. Studies on immune functions of peripheral T lymphocytes revealed an abrogation of cellular immune responses as early as 3-5 days after infection and thus before detection of viral antigens in these cells. The data suggest that early immunosuppression represents a crucial event for the manifestation of classical swine fever.

Keywords Pubmed: Animals
Antigens, CD/analysis
Cell Division
Classical Swine Fever/blood
Classical Swine Fever/immunology*
Humans
Phenotype
Swine
T-Lymphocyte Subsets/classification
T-Lymphocyte Subsets/immunology
T-Lymphocyte Subsets/virology
T-Lymphocytes/classification
T-Lymphocytes/immunology*
T-Lymphocytes/virology
Thymus Gland/cytology
Tumor Cells, Cultured
Viral Envelope Proteins/analysis


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